Cisapride(C23H29CIFN3O4) is one of the well-known prokinetic agents. It operates upon the whole gastrointestinal tract, from the lower esophageal sphincter to the anal sphincter, and holds the most promise for patients with colonic motility
disorders.
It is known to function as an indirect cholinergic stimulant through increased release of acetylcholine in the intramural plexuses. Unlike metoclopramide, it does not have the antidopaminergic effects on the central nervous system. But its effect
on the
biliary system has not been clearly elucidated. This study was performed in 12 healthy volunteers, and focused on the change of the volume of gallbladder after cisapride ingestion, during the fasting period and after meal. With the interval of
2-4days,
10mg of cisapride and placebo after 8 hours of fasting, and 20mg of cisapride and placebo with meal were given to each man, respectively. Cisapride increased the volume of gallbladder in the fasting period and inhibited the contraction of
gallbladder
after meal, compared with placebo. This suggest that cisapride can induces the possible cholelithiasis, but, on the other hand, it can be used as a possible spasmolytic agent in gallstone disease.
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